Combining exposure scenario information for mixtures with combination effects

The main aims of the present study were 1) to examine how the existing methods for combining component-based exposure scenario information for mixtures cover combination effects of the components, 2) to evaluate whether there is a need to develop further guidance to formulators for taking into consideration combination effects when combining exposure scenario information, and 3) to evaluate the usability of the Mixie software on combination effects in the REACH context. The report presents the outcomes of the study.